Sezione di

Fisiologia Umana

Laboratorio di fisiopatologia respiratoria

Componenti: prof. M. Pecchiari, prof. E. D'Angelo, R. Galli

Pubblicazioni dal 2010


Heliox administration in anesthetized rabbits with spontaneous inspiratory flow limitation.

D'Angelo EG, Pecchiari MM, Bellemare F, Cevenini G, Barbini P.

J Appl Physiol (1985). 2021 Jan 7. doi: 10.1152/japplphysiol.00830.2020. Online ahead of print.

PMID: 33411637


Tidal expiratory flow limitation induces expiratory looping of the alveolar pressure-flow relation in COPD patients.

Pecchiari M, Radovanovic D, Zilianti C, Saderi L, Sotgiu G, D'Angelo E, Santus P.

J Appl Physiol (1985). 2020 Jul 1;129(1):75-83. doi: 10.1152/japplphysiol.00664.2019. Epub 2020 Jun 5.

PMID: 32501776


The Relevance of Targeting Treatment to Small Airways in Asthma and COPD.

Santus P, Radovanovic D, Pecchiari M, Ferrando M, Tursi F, Patella V, Braido F.

Respir Care. 2020 Sep;65(9):1392-1412. doi: 10.4187/respcare.07237. Epub 2020 Mar 24.

PMID: 32209703 Review.


The development of various forms of lung injury with increasing tidal volume in normal rats.

D'Angelo E, Koutsoukou A, Della Valle P, Gentile G, Pecchiari M.

Respir Physiol Neurobiol. 2020 Mar;274:103369. doi: 10.1016/j.resp.2020.103369. Epub 2020 Jan 3.

PMID: 31911202


Lung Microbiome in Asthma: Current Perspectives.

Loverdos K, Bellos G, Kokolatou L, Vasileiadis I, Giamarellos E, Pecchiari M, Koulouris N, Koutsoukou A, Rovina N.

J Clin Med. 2019 Nov 14;8(11):1967. doi: 10.3390/jcm8111967.

PMID: 31739446 Free PMC article. Review.


The Airways' Mechanical Stress in Lung Disease: Implications for COPD Pathophysiology and Treatment Evaluation.

Santus P, Pecchiari M, Tursi F, Valenti V, Saad M, Radovanovic D.

Can Respir J. 2019 Sep 5;2019:3546056. doi: 10.1155/2019/3546056. eCollection 2019.

PMID: 31583033 Free PMC article. Review.


Expiratory flow-limitation in mechanically ventilated patients: A risk for ventilator-induced lung injury?

Koutsoukou A, Pecchiari M.

World J Crit Care Med. 2019 Jan 23;8(1):1-8. doi: 10.5492/wjccm.v8.i1.1. eCollection 2019 Jan 23.

PMID: 30697515 Free PMC article.


Standard and viscoelastic mechanical properties of respiratory system compartments in dogs: Effect of volume, posture, and shape.

D'Angelo E, Calderini E, Tavola M, Pecchiari M.

Respir Physiol Neurobiol. 2019 Mar;261:31-39. doi: 10.1016/j.resp.2018.12.003. Epub 2018 Dec 13.

PMID: 30553944


Plethysmographic Loops: A Window on the Lung Pathophysiology of COPD Patients.

Radovanovic D, Pecchiari M, Pirracchio F, Zilianti C, D'Angelo E, Santus P.

Front Physiol. 2018 May 1;9:484. doi: 10.3389/fphys.2018.00484. eCollection 2018.

PMID: 29765337 Free PMC article.


Limiting Factors in Walking Performance of Subjects With COPD.

Sanseverino MA, Pecchiari M, Bona RL, Berton DC, de Queiroz FB, Gruet M, Peyré-Tartaruga LA.

Respir Care. 2018 Mar;63(3):301-310. doi: 10.4187/respcare.05768. Epub 2017 Nov 21.

PMID: 29162719


Acute effects of long-acting bronchodilators on small airways detected in COPD patients by single-breath N2 test and lung P-V curve.

Pecchiari M, Santus P, Radovanovic D, DʼAngelo E.

J Appl Physiol (1985). 2017 Nov 1;123(5):1266-1275. doi: 10.1152/japplphysiol.00493.2017. Epub 2017 Aug 3.

PMID: 28775071


Understanding at-risk subgroups for lungfunction impairment in life-long nonsmokers with α1-antitrypsin deficiency.

Ortega VE, Pecchiari M.

Eur Respir J. 2017 Mar 29;49(3):1700114. doi: 10.1183/13993003.00114-2017. Print 2017 Mar.

PMID: 28356380 No abstract available.


Airway occlusion assessed by single breath N2 test and lung P-V curve in healthy subjects and COPD patients.

Pecchiari M, Radovanovic D, Santus P, D'Angelo E.

Respir Physiol Neurobiol. 2016 Dec;234:60-68. doi: 10.1016/j.resp.2016.09.006. Epub 2016 Sep 6.

PMID: 27612586


Improvements in Lung Diffusion Capacity following Pulmonary Rehabilitation in COPD with and without Ventilation Inhomogeneity.

Santus P, Radovanovic D, Balzano G, Pecchiari M, Raccanelli R, Sarno N, Di Marco F, Jones PW, Carone M.

Respiration. 2016;92(5):295-307. doi: 10.1159/000448847. Epub 2016 Sep 7.

PMID: 27598467


Friction and morphology of pleural mesothelia.

Pecchiari M, Sartori P, Conte V, D'Angelo E, Moscheni C.

Respir Physiol Neurobiol. 2016 Jan;220:17-24. doi: 10.1016/j.resp.2015.09.003. Epub 2015 Sep 12.

PMID: 26376001


Assessment of acute bronchodilator effects from specific airway resistance changes in stable COPD patients.

Santus P, Radovanovic D, Henchi S, Di Marco F, Centanni S, D'Angelo E, Pecchiari M.

Respir Physiol Neurobiol. 2014 Jun 15;197:36-45. doi: 10.1016/j.resp.2014.03.012. Epub 2014 Apr 12.

PMID: 24726342 Clinical Trial.


Effects of various modes of mechanical ventilation in normal rats.

Pecchiari M, Monaco A, Koutsoukou A, Della Valle P, Gentile G, D'Angelo E.

Anesthesiology. 2014 Apr;120(4):943-50. doi: 10.1097/ALN.0000000000000075.

PMID: 24270126


Esophageal pressure as an estimate of average pleural pressure with lung or chest distortion in rats.

Pecchiari M, Loring SH, D'Angelo E.

Respir Physiol Neurobiol. 2013 Apr 1;186(2):229-35. doi: 10.1016/j.resp.2013.02.006. Epub 2013 Feb 15.

PMID: 23416404


Pulmonary Dysfunction in COPD.

Spiropoulos K, Karkoulias K, Koulouris N, D'Angelo E.

Pulm Med. 2013;2013:535820. doi: 10.1155/2013/535820. Epub 2013 Apr 8.

PMID: 23691307 Free PMC article. No abstract available.


Mixed lubrication after rewetting of blotted pleural mesothelium.

Bodega F, Sironi C, Porta C, Pecchiari M, Zocchi L, Agostoni E.

Respir Physiol Neurobiol. 2013 Jan 15;185(2):369-73. doi: 10.1016/j.resp.2012.09.003. Epub 2012 Sep 13.

PMID: 22982215


Plasma membrane disruptions with different modes of injurious mechanical ventilation in normal rat lungs*.

Pecchiari M, Monaco A, Koutsoukou A, D'Angelo E.

Crit Care Med. 2012 Mar;40(3):869-75. doi: 10.1097/CCM.0b013e318232da2b.

PMID: 22001586


Effects of Heliox in Stable COPD Patients at Rest and during Exercise.

Pecchiari M.

Pulm Med. 2012;2012:593985. doi: 10.1155/2012/593985. Epub 2012 Oct 10.

PMID: 23094152 Free PMC article.


Lubricating effect of sialomucin and hyaluronan on pleural mesothelium.

Bodega F, Pecchiari M, Sironi C, Porta C, Arnaboldi F, Barajon I, Agostoni E.

Respir Physiol Neurobiol. 2012 Jan 15;180(1):34-9. doi: 10.1016/j.resp.2011.10.006. Epub 2011 Oct 17.

PMID: 22019600


Maintaining end-expiratory transpulmonary pressure prevents worsening of ventilator-induced lung injury caused by chest wall constriction in surfactant-depleted rats.

Loring SH, Pecchiari M, Della Valle P, Monaco A, Gentile G, D'Angelo E.

Crit Care Med. 2010 Dec;38(12):2358-64. doi: 10.1097/CCM.0b013e3181fa02b8.

PMID: 20890197 Free PMC article.


Motor control of the diaphragm in anesthetized rabbits.

D'Angelo E, Monaco A, D'Angelo E, Pecchiari M.

Respir Physiol Neurobiol. 2010 Feb 28;170(2):141-9. doi: 10.1016/j.resp.2009.11.007. Epub 2009 Nov 20.

PMID: 19932203